Dead Sea Minerals Study: New findings on skin and the biology beyond
The therapeutic properties of Dead Sea (DS) minerals are extensively documented, and their unique combination is analyzed and reported. DS water (DSW) is an important source of DS minerals, and numerous studies indicate that DSW can ease symptoms of various skin conditions and aid in skin maintenance. However, despite documented impacts, the biological mechanisms are not yet fully understood.
Using the expression of various skin biomarkers associated with barrier function, homeostasis, inflammation, and irritation, we sought to determine the effect of topically administered DSW.
To evaluate the biological effects of DSW, in vitro skin equivalents and ex vivo human skin organ cultures were utilized. On skin equivalents, epidermal barrier protein expression and DSW ion transdermal penetration were analyzed. On cultures of human skin organs, -endorphin secretion was examined. Ex vivo human skin organ cultures were treated with lipopolysaccharides and sodium dodecyl sulphate, respectively, to assess the efficacy of DSW to protect against skin inflammation and irritation.
This study offers fresh information regarding the impact of DSW on skin. Following skin exposure to DS minerals, specifically DSW, it is hypothesized that the activation of signaling pathways may result in a large array of demonstrated biological actions.